Liver failure Preface Introduction The Liver in Health Liver physiology Functional anatomy Blood Supply Introduction to Acute Liver Failure Definitions Epidemiology Aetiology Making the diagnosis Diagnosing acute liver failure History Presentation and clinical features Laboratory tests Liver biopsy Radiology Differential diagnosis Managing the acute situation Assessment of severity and prognosis in ALF Assessment of severity and prognosis in ACLF Providing organ support Central nervous system dysfunction Respiratory system dysfunction Coagulopathy Renal dysfunction Endocrine and metabolic support Cardiovascular support Management of the aetiology Monitoring key variables and trends in organ dysfunction Providing a safe physiological environment Toxin removal or treatment Minimising Complications and Providing Organ Support Minimising complications Central nervous system Cardiovascular system Respiratory system Coagulopathy Planning Advanced Treatment Options and Availability Specialist referral – criteria Transportation Liver transplantation Artificial liver support What is the Outcome from AHF? Relevance of background psychosocial factors Supporting the family Prognosis and outcomes following transplantation Conclusion Liver failure Acute Liver Failure Table of contents: Preface Liver failure Preface Introduction The Liver in Health Liver physiology Functional anatomy Blood Supply Introduction to Acute Liver Failure Definitions Epidemiology Aetiology Making the diagnosis Diagnosing acute liver failure History Presentation and clinical features Laboratory tests Liver biopsy Radiology Differential diagnosis Managing the acute situation Assessment of severity and prognosis in ALF Assessment of severity and prognosis in ACLF Providing organ support Central nervous system dysfunction Respiratory system dysfunction Coagulopathy Renal dysfunction Endocrine and metabolic support Cardiovascular support Management of the aetiology Monitoring key variables and trends in organ dysfunction Providing a safe physiological environment Toxin removal or treatment Minimising Complications and Providing Organ Support Minimising complications Central nervous system Cardiovascular system Respiratory system Coagulopathy Planning Advanced Treatment Options and Availability Specialist referral – criteria Transportation Liver transplantation Artificial liver support What is the Outcome from AHF? Relevance of background psychosocial factors Supporting the family Prognosis and outcomes following transplantation Conclusion Liver failure