Liver failure Preface Introduction The Liver in Health Functional anatomy Blood Supply Liver physiology Introduction to Acute Liver Failure Definition of ALF Epidemiology Aetiology Making the diagnosis Biological Criteria Determining aetiology Clinical presentation and assessment of complications Liver biopsy Imaging Assessment of severity and prognosis Assessment of severity and prognosis in ALF Assessment of severity and prognosis in ACLF Main Complications and Initial Management Cardiovascular Respiratory Renal Neurological Endocrine and metabolic support Coagulopathy Infection Complications Specific Treatment Acetaminophen toxicity Viral Hepatitis Amanita poisoning Wilson disease Autoimmune hepatitis Budd Chiari syndrome Pregnancy related ALF Planning Advanced Treatment Options Criteria for specialist referral Transportation Liver transplantation Artificial liver support Outcomes in Acute Liver Failure and Liver Transplantation Outcomes Relevance of Background Psychosocial Factors Supporting the Family Prognosis and Outcomes Following Transplantation Liver failure Acute Liver Failure Table of contents: Preface Introduction The Liver in Health Functional anatomy Blood Supply Liver physiology Introduction to Acute Liver Failure Definition of ALF Epidemiology Aetiology Making the diagnosis Biological Criteria Determining aetiology Clinical presentation and assessment of complications Liver biopsy Imaging Assessment of severity and prognosis Assessment of severity and prognosis in ALF Assessment of severity and prognosis in ACLF Main Complications and Initial Management Cardiovascular Respiratory Renal Neurological Endocrine and metabolic support Coagulopathy Infection Complications Specific Treatment Acetaminophen toxicity Viral Hepatitis Amanita poisoning Wilson disease Autoimmune hepatitis Budd Chiari syndrome Pregnancy related ALF Planning Advanced Treatment Options Criteria for specialist referral Transportation Liver transplantation Artificial liver support Outcomes in Acute Liver Failure and Liver Transplantation Outcomes Relevance of Background Psychosocial Factors Supporting the Family Prognosis and Outcomes Following Transplantation Liver failure Preface Introduction The Liver in Health Functional anatomy Blood Supply Liver physiology Introduction to Acute Liver Failure Definition of ALF Epidemiology Aetiology Making the diagnosis Biological Criteria Determining aetiology Clinical presentation and assessment of complications Liver biopsy Imaging Assessment of severity and prognosis Assessment of severity and prognosis in ALF Assessment of severity and prognosis in ACLF Main Complications and Initial Management Cardiovascular Respiratory Renal Neurological Endocrine and metabolic support Coagulopathy Infection Complications Specific Treatment Acetaminophen toxicity Viral Hepatitis Amanita poisoning Wilson disease Autoimmune hepatitis Budd Chiari syndrome Pregnancy related ALF Planning Advanced Treatment Options Criteria for specialist referral Transportation Liver transplantation Artificial liver support Outcomes in Acute Liver Failure and Liver Transplantation Outcomes Relevance of Background Psychosocial Factors Supporting the Family Prognosis and Outcomes Following Transplantation Liver failure