Acute Kidney Injury Preface Introduction Definition and diagnosis Introduction Executive summary Diagnosis of AKI functional parameters Diagnosis by AKI biomarkers E alerts Epidemiology Incidence Risk assessment and prediction models Patient outcomes Kidney outcome Pathophysiology Introduction Aetiology Pathology in ICU Connection between tubular injury and loss of GFR Pathophysiology of AKI in sepsis Pathophysiology of AKI in major surgery Pathophysiology of AKI in nephrotoxin exposure Contrast associated AKI Conclusion Diagnostic work up Introduction Diagnosis of AKI Diagnostic workup Prevention Fluids Diuretics Vasoactive drugs Drugs for AKI prevention Modifiable risk factors related to critical care Care bundles Conservative treatment Prediction of Progression or Need for RRT General Management Clinical practice Long term outcome Patient outcome Kidney outcome Acute Kidney Injury Acute Kidney Injury Table of contents: Preface Acute Kidney Injury Preface Introduction Definition and diagnosis Introduction Executive summary Diagnosis of AKI functional parameters Diagnosis by AKI biomarkers E alerts Epidemiology Incidence Risk assessment and prediction models Patient outcomes Kidney outcome Pathophysiology Introduction Aetiology Pathology in ICU Connection between tubular injury and loss of GFR Pathophysiology of AKI in sepsis Pathophysiology of AKI in major surgery Pathophysiology of AKI in nephrotoxin exposure Contrast associated AKI Conclusion Diagnostic work up Introduction Diagnosis of AKI Diagnostic workup Prevention Fluids Diuretics Vasoactive drugs Drugs for AKI prevention Modifiable risk factors related to critical care Care bundles Conservative treatment Prediction of Progression or Need for RRT General Management Clinical practice Long term outcome Patient outcome Kidney outcome Acute Kidney Injury